Wales were beaten by Scotland last year as tries from Tim Visser and Tommy Seymour ensured the men in blue ended a decade-long losing streak against the Welsh.
However, Cardiff is a less happy hunting ground for the Scots: they have not won there since 2002 and have lost 45 of their 61 encounters with Wales on foreign soil.
But they are better placed than ever before to buck those trends and secure an invaluable win over Warren Gatland’s side, having finished level on points for second place in the 2017 Six Nations and impressed in the autumn, beating Australia and coming close to New Zealand.
Express Sport brings you all the action from the Principality Stadium.
Wales 7 – Scotland 0 LIVE
2.23pm: An open start with both sides making progress but the home side draw first blood as Gareth Davies scores for Wales! Ali Price takes a couple of steps from the ruck, delaying his pass, that gives Davies enough time to get up and intercept. It’s a foot race over 50 metres against Chris Harris but the scrum-half has enough of a head-start to win it in the corner.
Halfpenny smashes the conversion from the touchline and it’s a nightmare start for Scotland.
2.15pm: Away we go! Scotland kick off the Six Nations 2018…
2.10pm: Let’s check out the teams before they come out for the anthems (best bit of the day sometimes when Wales play).
With so many injuries, there are more questions than answers. For me, the match-up between Rhys Patchell and Finn Russell at fly-half is an intriguing one.
Wales starting XV: Leigh Halfpenny; Josh Adams, Scott Williams, Hadleigh Parkes, Steff Evans; Rhys Patchell, Gareth Davies; Rob Evans, Ken Owens, Samson Lee, Cory Hill, Alun Wyn Jones, Aaron Shingler, Josh Navidi, Ross Moriarty.
Replacements: Elliot Dee, Wyn Jones, Tomas Francis, Bradley Davies, Justin Tipuric, Aled Davies, Gareth Anscombe, Owen Watkin.
Scotland starting XV: Stuart Hogg; Tommy Seymour, Chris Harris, Huw Jones, Byron McGuigan; Finn Russell, Ali Price; Gordon Reid, Stuart McInally, Jon Welsh, Ben Toolis, Jonny Gray, John Barclay, Hamish Watson, Cornell du Preez.
Replacements: Scott Lawson, Jamie Bhatti, Murray McCallum, Grant Gilchrist, Ryan Wilson, Greig Laidlaw, Pete Horne, Sean Maitland.
2pm: Barring Super Saturday, opening day of the Six Nations is one of my favourite days of the year. The tournament creeps up on you after Christmas but all of a sudden, the old rivalries are called upon again as a source of motivation and passion.
Wales are a bit of a blind spot for Scotland. Even at their best, they seem to come unstuck against the Welsh. Can they do it differently today? Only time will tell.
Kick-off, with the roof closed to keep out some forecast rain later on, is just 15 minutes away.