The Principality Stadium is sold out for the game, meaning 74,500 fans will be flocking to Cardiff and police estimate the number of people in the city overall will rise by around 100,000 people.
But because the UK terror threat level is currently “severe”, authorities in south Wales have asked fans to avoid bringing large bags to the stadium and arrive in the city as early as possible.
Similar measures were in place when Wales faced Australia in November but thousands of fans missed kick-off because of queues, something South Wales Police are keen to avoid.
“It’s not something that our rugby supporters will be used to if they didn’t come to a game in the autumn,” said Inspector Phillip Griffiths.
“We know we can get everyone in safely and securely and ensure they don’t miss a minute of the game, but we need supporters to help us.”
The stadium itself will open at 11.15am in an effort to ease congestion while roads around the ground will be shut from 10.45am.
Police are aiming to have admitted at least 30,000 fans to the ground by 12.45pm, an hour and a half before kick-off, to allow them to fill the stadium in time for kick off.
Scotland are 11/8 underdogs for the clash despite having beaten Wales last year.
The victory was their first in a decade against the Welsh but they have not won in Cardiff since a 27-22 triumph back in 2002.