That’s according to Jamie Redknapp, who says the Portuguese will prove the “biggest test” of Van Dijk’s career to date.
Cristiano Ronaldo is the Champions League’s all-time record goalscorer and he has already struck 15 times for Real this season.
The 33-year-old will be desperate to make his mark once again on Saturday night as Real target their third European title on the spin.
Ronaldo could play centrally once again in Kiev, which would pit him directly against Liverpool’s club-record signing Van Dijk.
Redknapp, who captained Liverpool during his playing career, has now revealed a worried admission ahead of the potential battle.
“[Mohamed] Salah may be the signing of the season but without Van Dijk, Liverpool would not be in Kiev,” Redknapp told the Daily Mail.
“He has made everyone around him look better and Liverpool’s defence are more organised with him in the team.
“In Cristiano Ronaldo, he faces the biggest test of his career.
“You can do all the preparation you like to stop Ronaldo and still he will find a way to score.
“Van Dijk may be 6ft 4in but Ronaldo can out-jump him.
“He cannot afford to switch off for one second — and he must make sure Liverpool’s defence don’t panic if they fall behind.”
Ronaldo is not the only Champions League hotshot looking to get on the scoresheet in Kiev though.
Mohamed Salah, Sadio Mane and Roberto Firmino have netted 29 goals in the competition between them this season.