CM Punk left the wrestling promotion after the 2014 Royal Rumble citing health reasons and frustration with his status in the company.
The six-time world champion then joined UFC but failed to impress in his first fight against Mickey Gall two years later as he tapped out on the first round.
Heyman hopes the ex-WWE Champion is solely focused on propelling his UFC career and becoming a great fighter.
The legendary manager told Digital Spy: “I don’t think Phil Brooks (CM Punk’s real name) thinks about WWE at all anymore. I would hope that he doesn’t.
“I would hope that he is of the focused mindset in propelling himself into the ranks of UFC.
“I don’t think it’s a matter of positioning or money or spotlight anymore.
“I think it’s a matter of his dream is to become a successful UFC fighter and he doesn’t even have a thought regarding WWE, at least I would hope that he doesn’t.
“Because I don’t know how it would be considered productive for him to do so.”
Heyman managed CM Punk in 2012 when he was WWE Champion and was in his corner in legendary matches against the likes of The Rock, The Undertaker and John Cena.
Their alliance ended a year later when the ECW legend betrayed CM Punk at Money in the Bank.
Heyman is still aligned with Universal Champion Brock Lesnar.
Rumours suggest Lesnar’s contract will run out after WrestleMania 34 and he may leave the company to rejoin UFC.
Heyman though isn’t expected to follow The Beast out of the company.
CM Punk is expected to have another UFC fight in the near future.